CLINICAL TRIALS

Cartiva™ SCI MOTION Study

A Prospective, Randomized, Non-Inferiority Study to Evaluate the
Effectiveness of Cartiva™ Synthetic Cartilage Implant in the Treatment
of First Metatarsophalangeal Joint Osteoarthritis as Compared to a Control.

Carticept is conducting the MOTION study to compare the effectiveness
of the Cartiva™ Synthetic Cartilage Implant to an arthrodesis control in the treatment of patients with osteoarthritis of the great toe, specifically the following clinical conditions: hallux valgus or hallux limitus, hallux rigidus, and an unstable or painful metatarsophalangeal (MTP) joint.

This is a prospective, randomized, controlled, multicenter trial. Patients are currently being enrolled in Canada and the United Kingdom.

For additional information, patients or physicians should contact
motion@carticept.com or 001-770-754-3800.