PRESS RELEASES

CARTICEPT MEDICAL™ CLOSES $10 MILLION SERIES C  FINANCING ROUND
Investment to Support Commercialization of its Navigator™ Delivery System 


(Alpharetta, GA, January 18, 2012)--Carticept Medical, Inc., a developer of innovative products for the treatment
of cartilage injuries and osteoarthritis, today announced that it has has completed a $10 million round of
financing, led by existing investors Domain Associates, New Enterprise Associates and SonoSite, Inc. The
financing will provide funding for the commercial launch of the Company’s Navigator™ Delivery System (DS), a
computer‐controlled drug delivery system that redefines medication delivery by integrating ultrasound guidance
to increase the efficiency, accuracy and safety of administering medications for joint pain. Carticept received
FDA 510(k) clearance to market the Navigator DS in September 2011, with the full commercial launch slated for
Q1 2012. This latest round of financing increases the venture capital investment in Carticept to a combined total
of $53 million.

Arthritis is the leading cause of disability in the United States with more than 46 million Americans having
doctor‐diagnosed arthritis.1 Local injections of corticosteroids and anesthetic agents are heavily relied on as
early, effective interventions for pain relief. The current standard of practice, ‘blind injection,’ depends on the
expertise of the clinician and the accuracy with which the medications are injected into the affected joint space.
According to a recent study published in The American Journal of Sports Medicine, injection accuracy rates are
significantly higher when imaging is used in conjunction with injection of the knee and shoulder.

The Navigator DS automates the preparation and delivery of injections using ultrasound to guide accurate
needle positioning. The automated system helps to ensure accurate dose preparation, while eliminating needle
exposure to healthcare workers and minimizing the potential for contamination. After the injection is delivered,
the system records the treatment data and automatically creates a record for transfer to an electronic record
management system.

“The support of our existing investors validates the investment community’s continued confidence in the vision
of the company and the benefits of our product platform to improve the efficiency and accuracy of injection
delivery,” said Timothy J. Patrick, president and chief executive officer of Carticept. “With the completion of this
financing, we are well positioned to launch the Navigator DS in leading orthopaedic and sports medicine centers
across the United States.”

About Carticept Medical, Inc.

Based in Alpharetta, Ga., Carticept Medical, Inc. is a privately held medical device company established in 2005
to develop and market innovative solutions for patients with osteoarthritis or cartilage damage. Major investors
include Domain Associates, New Enterprise Associates and SonoSite, Inc. Additional information is available on
the company’s website at www.carticept.com.

Media Contacts:

Krystin Hayward/Rachel Gross
carticept@schwartzmsl.com
781-684-0770 

1Arthritis: Meeting the Challenge. Atlanta, GA: National Center for Chronic Disease Prevention and
Health Promotion; 2009. [http://www.cdc.gov/NCCDPHP/publications/aag/pdf/arthritis.pdf]